鉤藤堿
分析標(biāo)準(zhǔn)品,HPLC≥98%
Rhyncholphylline
CAS號(hào)：76-66-4
分子式：C22H28N2O4
分子量：384.47
MDL：MFCD00221748
貨號(hào) | 規(guī)格/參數(shù)/品牌 | 價(jià)格 | 貨期 |
YJ-B20453-20mg | 分析標(biāo)準(zhǔn)品,HPLC≥98% | ￥700.00 | 現(xiàn)貨 |
產(chǎn)品介紹
熔點(diǎn)：216℃
沸點(diǎn)：560.8 ℃ at 760 mmHg
比旋光度：D13 -14.7° (c = 2.5 in chloroform)
外觀：白色結(jié)晶
溶解性：溶于氯仿、丙tong、乙醇、苯，微溶于乙mi和醋酸乙酯，幾乎不溶于石油醚。
儲(chǔ)存條件：2-8℃
注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。
參考文獻(xiàn)(28篇)
28. [IF=6] Tao Hu et al."Haploid-Phased Chromosomal Telomere-to-Telomere Genome Assembly of Medicinal Plant Uncaria rhynchophylla Dissects Genetic Controls on the Biosynthesis of Bioactive Alkaloids."PLANT CELL AND ENVIRONMENT.2024 Nov;:
27. [IF=6.9] Lei Panpan et al."Cell membrane chromatography relative competitive method for the accurate determination of relative KD values of drug-receptor interactions."ARCHIVES OF PHARMACAL RESEARCH.2024 Dec;:1-13
26. [IF=6.8] Lin Lin et al."Rhynchophylline as an agonist of sirtuin 3 ameliorates endothelial dysfunction via antagonizing mitochondrial damage of endothelial progenitor cells."BRITISH JOURNAL OF PHARMACOLOGY.2025 Mar;:
25. [IF=1.3] Yongzhou Yu et al."Integrated UPLC-MS and multivariate data processing approach to explore the chemical components of Uncaria rhynchophylla and its absorbed components in rats following oral adminstration."JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNO
24. [IF=3.024] Xuan Yu et al."An innovative extraction strategy for herbal medicine by adopting p-sulphonatocalix[6]/[8]arenes."PHYTOCHEMICAL ANALYSIS
23. [IF=5.811] Liu Jiao et al."Rhynchophylline Regulates Calcium Homeostasis by Antagonizing Ryanodine Receptor 2 Phosphorylation to Improve Diabetic Cardiomyopathy."Frontiers in Pharmacology. 2022 Apr;0:1375
22. [IF=6.529] Lingling Xie et al."Uncaria Rhynchophylla attenuates angiotensin Ⅱ-induced myocardial fibrosis via suppression of the RhoA/ROCK1 pathway."Biomed Pharmacother. 2022 Feb;146:112607
21. [IF=2.649] Long Hongyan et al."Rhynchophyllin attenuates neuroinflammation in Tourette syndrome rats via JAK2/STAT3 and NF‐κB pathways."Environ Toxicol. 2019 Oct;34(10):1114-1120
20. [IF=3] Qu Lala et al."Phenotypic assessment and ligand screening of ETA/ETB receptors with label-free dynamic mass redistribution assay."N-S Arch Pharmacol. 2020 Jun;393(6):937-950
19. [IF=3.935] Wenwen Huang et al."Rapid discovery of potentially vasodilative compounds from Uncaria by UHPLC/Q-Orbitrap-MS based metabolomics and correlation analysis."J Pharmaceut Biomed. 2021 Nov;206:114384
18. [IF=3.996] Jiang Pan et al."Neuroprotective Effects of Rhynchophylline Against Aβ1–42-Induced Oxidative Stress, Neurodegeneration, and Memory Impairment Via Nrf2–ARE Activation."Neurochem Res. 2021 Sep;46(9):2439-2450
17. [IF=4.759] Keyu Feng et al."Configuration of the ion exchange chromatography, hydrophilic interaction chromatography, and reversed-phase chromatography as off-line three-dimensional chromatography coupled with high-resolution quadrupole-Orbitrap mass spectrometry fo
16. [IF=1.908] Xin Wang et al."Stereoselective pharmacokinetic study of rhynchophylline and isorhynchophylline epimers in rat plasma by liquid chromatography–tandem mass spectrometry."Xenobiotica. 2017;47(6):479-487
15. [IF=3.935] Shuanglu Xie et al."Systematic identification and quantification of tetracyclic monoterpenoid oxindole alkaloids in Uncaria rhynchophylla and their fragmentations in Q-TOF-MS spectra."J Pharmaceut Biomed. 2013 Jul;81-82:56
14. 鄧向濤,張文周,張智強(qiáng).鉤藤堿納米混懸劑緩釋片制備、優(yōu)化與體外釋放評(píng)價(jià)[J].中草藥,2020,51(20):5128-5136.
13. 范素芳, 馬俊美, 劉茁,等. 高效液相色譜-串聯(lián)質(zhì)譜測(cè)定食品中15種有毒生物堿[J]. 食品科學(xué), 2018, 39(22):290-295.
12. 郭曉敏, 黃寶媛, 曾常青. 鉤藤生物堿提取物及其單體逆轉(zhuǎn)HepG2/ADM細(xì)胞耐藥活性的篩選[J]. 廣東藥學(xué)院學(xué)報(bào), 2018, 034(004):447-451.
11. 樊暉, 田原. 正交試驗(yàn)優(yōu)選天麻安神顆粒乙醇提取工藝[J]. 中國(guó)實(shí)驗(yàn)方劑學(xué)雜志, 2015, 21(7):21-23.
10. 劉明, 王慧森, 李更生. 春花降壓片的質(zhì)量標(biāo)準(zhǔn)研究[J]. 西北藥學(xué)雜志, 2020, v.35(03):9-12.
9. 張媛媛 曾慧婷 陳超 等. 以離子液體為流動(dòng)相添加劑的HPLC法分離并測(cè)定鉤藤中鉤藤堿和異鉤藤堿的含量[J]. 中國(guó)藥房 2019 v.30;No.663(21):77-82.
8. 龍國(guó)友 王美 孫剛. HPLC法測(cè)定安樂片中鉤藤堿和異鉤藤堿的含量[J]. 中國(guó)藥品標(biāo)準(zhǔn) 2017(4).
7. 李素珍, 唐振祥, 吳衛(wèi). 鉤藤堿脂質(zhì)體的制備及釋放度研究[J]. 中華中醫(yī)藥雜志, 2013, 028(012):3730-3732.
6. 趙興業(yè), 王穎慧, 崔曉鴿,等. 鉤藤堿雙層滲透泵控釋片的制備及處方優(yōu)化[J]. 中成藥, 2020, v.42(05):17-21.
5. 徐有偉, 黃真, 周洪雷,等. 藤菔降壓片質(zhì)量控制研究[J]. 中藥新藥與臨床藥理, 2015, 026(005):690-694.
4. 黃真, 周洪雷, 李運(yùn)倫,等. 藤菔降壓片指紋圖譜評(píng)價(jià)體系研究[J]. 遼寧中醫(yī)雜志, 2014, 041(006):1251-1253.
3. 閆瑞, 李凌軍, 李順. 天鉤降壓膠囊中鉤藤堿大鼠體內(nèi)藥動(dòng)學(xué)研究[J]. 山東中醫(yī)藥大學(xué)學(xué)報(bào), 2014, 000(003):257-259.
2. 李季, 李凌軍, 婁華偉. 天鉤降壓膠囊中鉤藤堿、異鉤藤堿大鼠在體腸吸收動(dòng)力學(xué)研究[J]. 中國(guó)實(shí)驗(yàn)方劑學(xué)雜志, 2013, 19(6):167-170.
1. 婁華偉, 李凌軍, 李季. 天鉤降壓膠囊中鉤藤堿、異鉤藤堿在大鼠離體小腸的吸收動(dòng)力學(xué)研究[J]. 中國(guó)實(shí)驗(yàn)方劑學(xué)雜志, 2013, 19(7):150-153.
